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Detailed description of the statistical strategies employed for variable transformation and selection is provided in the appendix (Appendix B).

The transformations we employed were (a) none (variable introduced in models as a linear term), (b) quadratic polynomial (the variable and its square), and (c) cubic polynomial (variable, its square, and its cube). We kept the highest, lowest and most deranged vital sign recorded in the past 24 h; for laboratory tests, we took the most recent value in the past 72 h.